Description
Sermorelin 10mg (Lyophilized Peptide) – For Research Purposes Only
Product Details
Catalog #: SER-10MG
Form: Lyophilized (freeze-dried) powder
Purity: ≥99% (HPLC verified)
Quantity: 10mg per vial
Storage: Before reconstitution: -20°C / After reconstitution: 2-8°C
Shipping: Ambient temperature with ice pack (temperature-sensitive)
Key Research Applications
- Growth hormone releasing hormone (GHRH) receptor studies
- Pulsatile growth hormone secretion investigations
- IGF-1 modulation and endocrine signaling research
- Sleep architecture and circadian rhythm studies
- Lean body mass and metabolic regulation research
- Neuroendocrine aging and pituitary function investigations
Handling
Reconstitute with sterile bacteriostatic water. Gently swirl – do not vortex. Aliquot to avoid freeze-thaw cycles.
⚠️ Important:
This product is supplied for in vitro and animal research exclusively. Not for diagnostic, therapeutic, or human use. Must be handled by qualified personnel with appropriate PPE.
Overview
Sermorelin is a synthetic peptide analog consisting of the first 29 amino acids of endogenous Growth Hormone-Releasing Hormone (GHRH 1-29), the biologically active portion responsible for stimulating pituitary growth hormone secretion. Originally developed for endocrine and metabolic research, Sermorelin has been extensively studied in preclinical and clinical investigations involving growth hormone dynamics, neuroendocrine regulation, sleep physiology, body composition, and age-related hormonal decline.
This 10mg lyophilized preparation is intended exclusively for in vitro and in vivo research applications, including receptor binding assays, endocrine pathway studies, animal model investigations, and analytical method development. This product is not intended for human or veterinary use outside of regulated laboratory settings.
Chemical & Physical Properties
Molecular Formula: C₁₄₉H₂₄₆N₄₄O₄₂S
Molecular Weight: 3357.9 g/mol
Sequence: Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂
Appearance: White to off-white lyophilized cake or powder
Solubility: Soluble in sterile water for injection, PBS (pH 5–6), or bacteriostatic water. Avoid vigorous shaking.
Stability: Stable when stored as directed. Avoid repeated freeze-thaw cycles after reconstitution.
Primary Research Applications
Researchers have utilized Sermorelin in controlled laboratory studies to examine the following mechanisms and physiological effects:
1. Growth Hormone Release & Pituitary Function
Mechanism of Action
Sermorelin selectively binds to GHRH receptors located in the anterior pituitary gland, stimulating pulsatile secretion of endogenous growth hormone (GH). Unlike direct GH administration, Sermorelin preserves normal physiological feedback regulation.
Research has demonstrated:
- Increased pulsatile GH secretion
- Elevation of circulating insulin-like growth factor-1 (IGF-1)
- Preservation of pituitary responsiveness
- Potential enhancement of hypothalamic-pituitary signaling integrity
Research Applications & Findings
Preclinical endocrine studies have utilized Sermorelin to evaluate:
- Age-related GH decline
- Pituitary reserve capacity
- Somatotropic axis regulation
- Hormonal pulsatility patterns
Typical animal model investigations have observed dose-dependent increases in circulating GH and IGF-1 concentrations following administration.
2. Sleep Architecture & Neuroendocrine Regulation
Mechanism of Action
Growth hormone secretion is closely linked with slow-wave sleep (SWS). Sermorelin has been investigated for its ability to influence sleep quality through modulation of nocturnal GH pulses.
Studies have explored:
- Enhancement of deep sleep phases
- Circadian endocrine synchronization
- Neuroendocrine stress response modulation
- Recovery physiology and restorative sleep processes
Research Applications
Animal and laboratory studies have examined:
- Sleep fragmentation models
- Aging-associated sleep decline
- Stress-induced endocrine disruption
- CNS signaling pathways involving hypothalamic regulation
3. Metabolic & Body Composition Research
Mechanism of Action
By increasing endogenous GH and downstream IGF-1 signaling, Sermorelin has become a subject of interest in metabolic regulation studies.
Research indicates potential involvement in:
- Lipolysis and fat metabolism
- Lean tissue preservation
- Protein synthesis signaling
- Glucose utilization pathways
- Exercise recovery physiology
Research Applications
Investigators have used Sermorelin in:
- Obesity-related metabolic studies
- Sarcopenia and aging models
- Exercise physiology research
- Catabolic stress investigations
Observed effects remain dose-dependent and species-specific.
4. Neuroprotective & Cognitive Research
Mechanism of Action
GH and IGF-1 signaling pathways are associated with neuroplasticity, neuronal survival, and hippocampal function. Sermorelin has therefore been explored in neuroendocrine and cognitive research models.
Research areas include:
- Neurogenesis and synaptic plasticity
- Cognitive decline models
- Memory and learning pathways
- Neuroinflammatory regulation
- Aging-associated neurological changes
Research Applications
Experimental investigations have evaluated:
- Cognitive performance under stress conditions
- Neurodegenerative disease models
- Age-associated endocrine decline
- CNS repair and regeneration pathways
Quality Assurance & Testing
Each batch of Sermorelin 10mg undergoes rigorous quality control prior to release:
- HPLC Purity: ≥99% (chromatogram available upon request)
- Mass Spectrometry (MS): Confirmed molecular weight within ±0.05% of theoretical
- Residual Solvent Analysis: Meets ICH Q3C guidelines
- Endotoxin Testing: <1.0 EU/mg (LAL assay)
- Sterility: 0.22µm filtered prior to lyophilization
A Certificate of Analysis (CoA) is provided with each shipment.
Reconstitution & Handling Protocol (For Laboratory Use Only)
- Allow the sealed vial to reach room temperature before opening to avoid condensation.
- Add 1–2 mL of sterile bacteriostatic water or 0.9% sterile saline to the lyophilized powder.
- Swirl gently – do not vortex or shake vigorously, as peptides can denature.
- Allow to dissolve fully (typically 1–3 minutes). Solution should be clear and particle-free.
- Aliquot to avoid freeze-thaw cycles and store at 2–8°C for up to 30 days. For longer storage, freeze at -20°C in single-use aliquots.
Typical Research Dosing (Animal Models)
0.1 – 0.5 mg/kg via subcutaneous (SC) or intraperitoneal (IP) administration depending on species and study design. Route and dose must be determined by the principal investigator.
Safety & Legal Disclaimer
⚠️ FOR RESEARCH PURPOSES ONLY. NOT FOR HUMAN OR VETERINARY USE.
This product is not a drug, medicine, dietary supplement, or food additive.
Not for diagnostic, therapeutic, or recreational use.
Not approved by the FDA, EMA, MHRA, or any other regulatory agency for human consumption.
Use only by qualified researchers in appropriately equipped laboratories.
Do not administer to humans or companion animals under any circumstances.
Must be handled with appropriate personal protective equipment (PPE) including gloves, lab coat, and eye protection.
By purchasing this product, you affirm that you are at least 18 years of age and that you will use Sermorelin 10mg exclusively for lawful research purposes.
References (Selected Peer-Reviewed Literature)
- Walker, R. F., et al. (1986). Clinical Endocrinology, 25(4), 437–445.
- Vance, M. L., et al. (1989). Journal of Clinical Endocrinology & Metabolism, 68(4), 661–666.
- Ghigo, E., et al. (1990). Hormone Research, 33(1), 6–10.
- Corpas, E., et al. (1992). Journal of Clinical Endocrinology & Metabolism, 75(2), 530–535.
Full reference list available upon request.
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