Description
IGF-1 LR3 1MG – Premium Research Peptide for Growth Factor Studies
High-Purity Long IGF-1 LR3 for Advanced Laboratory Research
At NeuroForge Peptides, we offer IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) 1MG, a high-purity research peptide designed for controlled laboratory investigations into cellular signaling, receptor binding, and growth factor pathways. This recombinant analog of human IGF-I is engineered for enhanced stability and potency in research settings, making it a valuable tool for qualified scientists and researchers.
Why Choose Our IGF-LR3 1MG?
✔ 1MG lyophilized format – Standardized for research workflows
✔ ≥98% purity – Verified by HPLC and mass spectrometry
✔ Extended half-life analog – Modified for reduced IGFBP binding
✔ Lot-coded traceability – Tamper-evident packaging
✔ Certificate of Analysis included – Batch-specific verification
Scientific Background: Understanding IGF-1 LR3
What Is IGF-1 LR3?
IGF-1 LR3 (Long R3 Insulin-like Growth Factor-I) is a recombinant analog of human IGF-I, comprising the complete IGF-I sequence with an Arginine substitution at position 3 (replacing Glutamic acid) and a 13-amino-acid N-terminal extension peptide. These modifications confer markedly reduced binding affinity to IGF binding proteins (IGFBPs) , which normally inhibit IGF biological activity. The result is significantly enhanced potency and a prolonged half-life compared to native IGF-1.
Key Specifications:
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Molecular Weight: ~9.1 kDa (83 amino acid residues)
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Molecular Formula: C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₇ (approximately)
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Expression System: E. coli
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Endotoxin Level: <1 EU/μg
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Specific Activity: ED₅₀ ≤ 2.0 ng/ml in FDC-P1 cell proliferation assays
Mechanism of Action
The IGFs are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro. IGF-1 LR3 signals through the tyrosine kinase type I receptor (IGF-IR) , activating downstream pathways involved in cellular proliferation and differentiation. Because of its reduced IGFBP binding, IGF-1 LR3 demonstrates approximately three times the potency of native IGF-1 in research models.
Research Applications
Primary Areas of Investigation
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Growth factor pathway investigations
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Cell signaling interaction studies
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Receptor-binding dynamics analysis
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Intracellular signaling cascade modeling
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Peptide mechanism-focused investigations
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Muscle cell proliferation and differentiation studies
Laboratory Research Context
In experimental models, IGF-1 LR3 has been investigated for its potential effects on muscle tissue in controlled settings. One preclinical study using a rodent model of volumetric muscle loss found that high-dose PLGA-encapsulated IGF-1 LR3 led to increased muscle weight, though no improvement in neuromuscular function was observed. These findings highlight the importance of rigorous research protocols and further investigation into optimal delivery methods.
In vitro studies have shown that both IGF-I and IGF-1 LR3 significantly increase myoblast proliferation and protein levels in differentiating skeletal muscle cultures. The analog’s enhanced stability makes it particularly valuable for cell culture applications requiring sustained growth factor activity.
Protocol Guidance for Research Use
Commonly Researched Parameters
| Parameter | Typical Research Range | Notes |
|---|---|---|
| Daily Dose | 20-80 mcg | Derived from animal models and anecdotal reports; no human RCT data establishes safe or effective human doses |
| Frequency | Once daily | Consistent with extended half-life (20-30 hours in preclinical data) |
| Route | Subcutaneous or intramuscular | SubQ in abdominal or thigh tissue is predominant |
| Cycle Length | 4-6 weeks | Anecdotal protocol citing receptor desensitization concerns |
| Off Period | 4-6 weeks minimum | Precautionary convention, not clinically validated |
Preparation and Storage
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Lyophilized powder: Store at -20°C to -80°C, protected from moisture
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Reconstitution: Use bacteriostatic water; aliquot and store at -20°C
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Avoid repeated freeze-thaw cycles
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Reconstituted solutions at 2-8°C should be used within 1 week
Safety and Compliance Information
Regulatory Status
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WADA Prohibited – IGF-1 and its analogs are banned under the S2 Peptide Hormones and Growth Factors category. LC-MS/MS assays can distinguish IGF-1 LR3 from endogenous IGF-1 by sequence differences
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Research Use Only – This product is sold for laboratory research purposes only and is not for human or veterinary use
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Not FDA Approved – Not approved for clinical, therapeutic, or diagnostic applications
Research Considerations
Due to its structural similarity to insulin and cross-reactivity with the insulin receptor at supraphysiologic concentrations, researchers should exercise appropriate laboratory precautions. The extended half-life of IGF-1 LR3 (~20-30 hours) may have implications for experimental design and data interpretation.
Why Choose NeuroForge Peptides for Research Peptides?
Quality Assurance
HPLC-verified purity – ≥98% by HPLC and mass spectrometry
Lot-coded traceability – Batch-specific documentation maintained
Certificate of Analysis included – Supporting research verification
Tamper-evident packaging – Secure and professional presentation
Service Advantages
Fast U.S. shipping – Reliable delivery for research timelines
Secure checkout – Payment processing with researcher privacy in mind
Research support available – Assistance with product information and protocols
Frequently Asked Questions
1. What is IGF-1 LR3 and how does it differ from native IGF-1?
IGF-1 LR3 is a modified analog of IGF-1 featuring an arginine substitution at position 3 and a 13-amino-acid N-terminal extension. These modifications greatly reduce binding to IGF binding proteins, resulting in an extended half-life and enhanced potency in research applications.
2. What purity standard should I expect?
Our IGF-1 LR3 is verified at ≥98% purity by HPLC and mass spectrometry, supported by batch-specific Certificates of Analysis.
3. Is this product approved for human use?
No. This product is for laboratory research use only (RUO) and is not intended for human or veterinary use, clinical applications, or therapeutic purposes.
4. What research protocols are commonly used?
Typical research protocols use 20-80 mcg per day administered subcutaneously, with 4-6 week study periods followed by off periods. These figures are derived from animal pharmacology and anecdotal reports, not controlled human trials.
5. How should I store the product?
Store lyophilized powder at -20°C to -80°C. After reconstitution, aliquot and store at -20°C, avoiding repeated freeze-thaw cycles. Reconstituted solutions can be stored at 2-8°C for up to one week.
Order Your IGF-1 LR3 1MG Research Peptide Today
For laboratory research use only
High-purity peptide – 1MG format
Lot-coded and tamper-evident packaging
Fast U.S. shipping
Disclaimer: This product is sold for laboratory research purposes only. Not for human or veterinary use. Not approved for clinical, therapeutic, or diagnostic applications. This product is not a drug, food, dietary supplement, cosmetic, or medical device. Researchers assume all responsibility for proper handling and disposal in accordance with applicable regulations.
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